General Research Summary

Molecular Genetics Laboratory

Overall, our research has been focused on understanding eukaryotic transcriptional regulation. In particular, we are interested in studying transcription mechanisms including RNA Polymerase II (Pol II) promoter proximal pausing and pause release during early transcriptional elongation as an important transcriptional checkpoint to regulate the gene expression of a large number of developmental and stimulus-inducible protein-coding and non-protein coding genes.